|
KMID : 0388419990080020089
|
|
Konkuk Journal of Medical Sciences
1999 Volume.8 No. 2 p.89 ~ p.98
|
|
|
A Diagnosis of Premature Rupture of Membranes by Identification of Human Chorionic Gonadotropin
|
|
Sohn In-Sook
Lee Won-Wook
You Yeon-Wung
Kim Young-Moon
Lee Sung-Ki
Kim Soo-Nyung
Choi Young-Sook
|
|
|
Abstract
|
|
|
Our purpose was to determine whether the measurement of hCG levels in vaginal fluid is useful for the diagnosis of premature rupture of membranes(PROM). 81 pregnant women participated in the study. Second trimester(12 cases) and third trimester normal pregnant women(40 cases) who had no evidence of placenta previa, premature rupture of membranes(PROM) of preterm labor were enrolled in the control group. Consenting patients(n=29) with complaint membrane rupture between second and third trimester of gestation who had no evidence of placenta previa or labor were enrolled in the study group. The diagnosis of membrane rupture required at least two of the following findings on vaginal examination: vaginal pooling of fluid, positive Nitrazine paper test, or positive fetal fibronectin test. As this results, confirmed PROM group(18 cases) and suspicious PROM group(11 cases) is divided. After irrigating the posterior
vaginal fornix with 3 mL of sterile saline, we measured hCG levels. Data analysis included Fisher-Exact test, χ2 test, t-test. The mean and standard deviation of vaginal fluid hCG level of normal pregnant women
were 43.08±42.61, 21.60±22.63 mIU/mL during the second and third trimesters, respectively. That of women with confirmed PROM and suspicious PROM were 565.5± 884.23, 12.73±7.64 mIU/mL, respectively. Using a hCG threshold value of 50 mIU/mL, sensitivity was 83.3%, specificity 66.7%, positive predictive value 78.9%, negative predictive value 72.7%, accuracy 76.7% between the second trimester normal control and confirmed PROM group; and sensitivity was 83.3%, specificity 95.0%, positive predictive value 88.2%, negative predictive value 92.7%, accuracy 91.4% between the third trimester normal control and confirmed PROM group; sensitivity was 83.3%, specificity 100%, positive predictive value 100%, negative predictive value 78.6%, accuracy 89.6% between confirmed and suspected PROM group. The hCG level in the vaginal fluid is a useful additive marker of PROM during third trimester when the rupture is only suspected.
|
|
|
KEYWORD
|
|
|
premature rupture of membranes, human chorionic gonadotropin
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|